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卧虎藏龙而又凌乱不堪的13区在上一部《暴力街区》时间设定的两年后再次陷入了大宗阴谋事件，达米安上尉（西里尔?拉法埃利 Cyril Raffaelli 饰）与雷伊托（大卫?贝利 David Belle 饰）这次的对手是不择手段的房地产商——13区将因他的房地产计划而毁灭。在利益集团实施一系列精心筹备的栽赃行动后，13区的暴力一面被推向媒体的风口浪尖，13区一时间成为国民心中残暴的象征；达米安又身陷囹圄，极度不利的局势下，雷伊托成为13区最后的希望，他能否营救达米安并联合13区内的五大势力最后将真相呈献给总统以拆穿不法商人的阴谋呢？
Five years since SIENA gained the ability to see when someone will die, Siena still often feels consumed by fear, a secret she even hides from her two friends, WINDY and RIO. Siena only confides in NAYA, a professor and clinical psychologist on campus. Then, one day, a death occurs on campus, but this time Siena sees no sign. This event prompts Naya to return to her hometown, Remetuk Village, to meet with LARAS. Armed with a message left behind, Siena is accompanied by Windy and Rio on a journey to Remetuk Village. As harvest season approaches, suicide attempts are a recurring theme in Remetuk Village, but Siena, who wants to help, has never been able to see the signs. Siena, Windy, Rio, Naya, and Naya and Laras, none of them can escape this curse, the desire in each of them to know and determine when they will die.