“败金女”文佳佳（汤唯 饰）曾经是美食杂志编辑，对爱情充满了像电影《西雅图夜未眠》一样的浪漫幻想。而在现实中，为了给自己的孩子一个“美利坚公民”的身份，她不远万里只身来到西雅图的月子中心待产生子。 在月子中心，文佳佳炫富的作风引发了房东（金燕玲 饰）和其他孕妇周逸（海清 饰）、陈悦（买红妹 饰）的反感，倍感孤独的她只能向司机郝志Frank（吴秀波 饰）倾诉心声。而看上去木讷老实的“落魄叔”Frank并不是一个平庸的男子，他在中国曾是一位一流的心血管疾病方面的名医。在相处中，Frank的体贴包容渐渐融化着文佳佳的刁蛮任性。当文佳佳的富豪男友突然失踪后，一夜之间变成穷人的文佳佳得到了Frank无微不至的照顾，跟Frank和他的女儿Julie（宋美曼 & 宋美慧 饰）一起生活的这段日子，让文佳佳找到了家的温暖。 当经历了变故的文佳佳，生下了孩子，就要结束她...
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Upon moving into her husband's childhood home to help take care of his elderly relatives, Jean Copeland, an emotionally withdrawn wife and mother of two, becomes embroiled in an affair with a suicidal lover. Her husband, Gordon, is oblivious, too busy worrying that he's losing his most prized possession, his mind, after a run-in with an ex-girlfriend he doesn't remember. 19-year-old, Priscilla, is a fashionista desperate to become a reality TV star, while 9-year-old crossword fanatic, Otis, has fallen in love for the very first time. Otis (played by Noah schanpp) falls in love with Caterina (played by Caroline Mills) after, well, forever. With Gordon's father, Theodore, fading into dementia, and 95-year old matriarch, Vivian, desperately clinging to control of the house, the six family members, at five stages of life, distill the dreams, worries, and regrets, of contemporary America.
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